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GenomicsGenome-wide maps of chromatin states during B-cell to Macrophage lineage switching
Using homogenous populations of cells undergoing lineage switching we studied enhancer nucleation. Examination of 3 histone marks several time points after induction of transdifferentiation
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-53173 | biostudies-arrayexpress
GenomicsGenome-wide maps of transcription factor and co-factor binding during B-cell to Macrophage lineage switching
Using homogenous populations of cells undergoing cell switching we observed an interplay between lymphoid and myeloid transcription factors during lineage switching Examination of transcription factors genome-wide binding profiles several time points after induction of B-cell to macrophage lineage s...
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-53362 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
GenomicsNucleosome density map during B-cell to Macrophage lineage switching
Using homogenous populations of cells undergoing lineage switching we studied enhancer nucleation related to nucleosme organization. Examination of nucleosome densities by using Mnase-seq at several time points after induction of lineage switching
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-53460 | biostudies-arrayexpress
Models,MultiomicsLymphoid and myeloid cell specification and transdifferentiation
Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and...
8186 | Cell Collective
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