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TranscriptomicsTranscription profiling of Arabidopsis during pathogen and insect attack
Plant defenses against pathogens and insects are regulated differentially by cross-communicating signaling pathways in which salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) play key roles. To understand how plants integrate pathogen- and insect-induced signals into specific defense respons...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5525 | biostudies-arrayexpress
TranscriptomicsChronic hypoxia in patients with colon carcinoma
In Western countries, colorectal cancer (CRC) is the third most common cancer in both men and women and the second leading cause of cancer-related deaths (approximately 500,000 deaths annually). For CRC, the tumor stage is the main prognostic factor for survival or relapse after surgery. Current sta...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-31079 | biostudies-arrayexpress
TranscriptomicsTranscriptome changes of Arabidopsis during pathogen and insect attack
Plant defenses against pathogens and insects are regulated differentially by cross-communicating signaling pathways in which salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) play key roles. To understand how plants integrate pathogen- and insect-induced signals into specific defense respons...
ORGANISM(S): Arabidopsis thaliana 
2006-08-15 | GSE5525 | GEO
TranscriptomicsLong-term Exposure to Sorafenib of Liver Cancer Cells Induces Resistance with Epithelial-to-Mesenchymal Transition, Increased Invasion and Risk of Rebound Growth
Sorafenib leads to a survival benefit in patients with advanced hepatocellular carcinoma but its use is hampered by the occurrence of drug resistance. To investigate the molecular mechanisms involved we developed five resistant human liver cell lines in which we studied morphology, gene expression a...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-62813 | biostudies-arrayexpress
ProteomicsDisturbed Balance of Protein Phosphatase Type 2A (PP2A) is Driving Epithelial-to-Mesenchymal Transition in Human Pan-creatic Cancer Patients
The incidence for pancreatic ductal adenocarcinoma (PDAC) is rising which has a low survival rate. In cancer, Epithelial-to-Mesenchymal transition (EMT) contribute to an aggressive phenotype. Protein Phosphatase Type 2A (PP2A) are initially regarded as tumor suppressors, the connection with EMT in p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037976 | Pride
Pancreatic cancer  epithelial-to-mesenchymal progression  protein phosphatases type 2a  gene expression  proteomics  in vivo results  drug target 
Unknown"Sickenin' in the rain" - increased risk of gastrointestinal and respiratory infections after urban pluvial flooding in a population-based cross-sectional study in the Netherlands.
Not available
S-EPMC6498475 | biostudies-literature
TranscriptomicsCombining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.
Objective: Insights about differences in tumor vasculature and how it reacts to VEGF inhibition is limited, but nevertheless of major relevance to anti-angiogenic therapy. In this study we therefore characterize the effect of bevacizumab combined with chemoradiotherapy (CRT), and explore molecular a...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-60331 | biostudies-arrayexpress
TranscriptomicsGene expression in liver of morbidly obese patients
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patient...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-59045 | biostudies-arrayexpress
TranscriptomicsGene expression in subcutaneous and visceral fat predicts liver histology in morbidly obese patients
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patient...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-58979 | biostudies-arrayexpress
TranscriptomicsChronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma
Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote ...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15366 | biostudies-arrayexpress
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