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ProteomicsDisturbed Balance of Protein Phosphatase Type 2A (PP2A) is Driving Epithelial-to-Mesenchymal Transition in Human Pan-creatic Cancer Patients
The incidence for pancreatic ductal adenocarcinoma (PDAC) is rising which has a low survival rate. In cancer, Epithelial-to-Mesenchymal transition (EMT) contribute to an aggressive phenotype. Protein Phosphatase Type 2A (PP2A) are initially regarded as tumor suppressors, the connection with EMT in p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037976 | Pride
Pancreatic cancer  epithelial-to-mesenchymal progression  protein phosphatases type 2a  gene expression  proteomics  in vivo results  drug target 
TranscriptomicsLong-term Exposure to Sorafenib of Liver Cancer Cells Induces Resistance with Epithelial-to-Mesenchymal Transition, Increased Invasion and Risk of Rebound Growth
Sorafenib leads to a survival benefit in patients with advanced hepatocellular carcinoma but its use is hampered by the occurrence of drug resistance. To investigate the molecular mechanisms involved we developed five resistant human liver cell lines in which we studied morphology, gene expression a...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-62813 | biostudies-arrayexpress
TranscriptomicsGene expression in liver of morbidly obese patients
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patient...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-59045 | biostudies-arrayexpress
TranscriptomicsGene expression in subcutaneous and visceral fat predicts liver histology in morbidly obese patients
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patient...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-58979 | biostudies-arrayexpress
TranscriptomicsCombining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.
Objective: Insights about differences in tumor vasculature and how it reacts to VEGF inhibition is limited, but nevertheless of major relevance to anti-angiogenic therapy. In this study we therefore characterize the effect of bevacizumab combined with chemoradiotherapy (CRT), and explore molecular a...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-60331 | biostudies-arrayexpress
TranscriptomicsChronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma
Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote ...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15366 | biostudies-arrayexpress
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