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UnknownDesign of a consensus-based geriatric assessment tailored for older chronic kidney disease patients: results of a pragmatic approach.

Purpose

Unidentified cognitive decline and other geriatric impairments are prevalent in older patients with advanced chronic kidney disease (CKD). Despite guideline recommendation of geriatric evaluation, routine geriatric assessment is not common in these patients. While high burden of vasc...
S-EPMC8463384 | biostudies-literature
UnknownAdded Value of a Blinded Outcome Adjudication Committee in an Open-Label Randomized Stroke Trial.

Background and purpose

Blinded outcome assessment in trials with prospective randomized open blinded end point design is challenging. Unblinding can result in misclassified outcomes and biased treatment effect estimates. An outcome adjudication committee assures blinded outcome assessment, b...
S-EPMC8700318 | biostudies-literature
UnknownDaily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial.

Background

Mucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic administration because lower doses are required for protection. Clinical development of mucosal mAbs is a highly active field yet clinical proof-of-concept ...
S-EPMC10772232 | biostudies-literature
UnknownSerum Potassium and Mortality Risk in Hemodialysis Patients: A Cohort Study.

Rationale & objective

Both hypo- and hyperkalemia can cause fatal cardiac arrhythmias. Although predialysis serum potassium level is a known modifiable risk factor for death in patients receiving hemodialysis, especially for hypokalemia, this risk may be underestimated. Therefore, we investi...
S-EPMC8767120 | biostudies-literature
UnknownPancreatic cancer risk and survival in patients with Lynch syndrome: a nationwide Dutch cohort study.

Background

Individuals with Lynch syndrome (LS) are advised to undergo pancreatic ductal adenocarcinoma (PDAC) surveillance if their lifetime risk is ≥5%, however, evidence is limited. This study quantifies lifetime risk and survival of three cancers relevant to PDAC surveillance, including ...
S-EPMC12828513 | biostudies-literature
UnknownT-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment.

Background

Aging-associated noncommunicable comorbidities are more prevalent among human immunodeficiency virus type 1 (HIV)-infected individuals than among HIV-uninfected individuals. Residual HIV-related chronic immune activation and senescence may increase the risk of developing comorbidi...
S-EPMC8445638 | biostudies-literature
UnknownAssessment of Recurrent Stroke Risk in Patients With a Carotid Web.

Importance

A carotid web (CW) is a shelf-like lesion along the posterior wall of the internal carotid artery bulb and an underrecognized cause of young stroke. Several studies suggest that patients with symptomatic CW have a high risk of recurrent stroke, but high-quality data are lacking.
S-EPMC8111564 | biostudies-literature
UnknownHealthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials.

Importance

The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known.

Objective

To assess the lifetime outcomes associated with speed of endovascular thrombectomy in...
S-EPMC8094030 | biostudies-literature
UnknownTrans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10-9, including 71 n...
S-EPMC7480402 | biostudies-literature
UnknownGenetic architecture of subcortical brain structures in 38,851 individuals.
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in al...
S-EPMC7055269 | biostudies-literature
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