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ProteomicsSILAC proteomics analysis to assess differences in protein expression upon BRCA2 inactivation
BRCA2 maintains genome stability by facilitating DNA repair via homologous recombination and replication fork stability. Loss of BRCA2 is deleterious for survival of normal cells, but is paradoxically tolerated in cancer cells. Using quantitative mass-spectrometry, differences in protein expression ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD007253 | Pride
Silac breast cancer brca2 hcc38 
ProteomicsThe FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin
Joint DNA molecules are natural by-products of DNA replication and repair. Persistent joint molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, which compromise sister chromatid separation. The DNA translocase PICH (ERCC6L) plays a central role in UFB resolution. To better understand the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD035876 | Pride
Homologous recombination rad51 c1orf112 dna repair flag ip 
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