A targeted metabolomics approach reveals distinct metabolic patterns associated with different GOLD stages, KNGF profiles and SYS subtypes in COPD patients, highlighting unique mechanisms and pathways underlying various COPD classification systems.
Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...