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TranscriptomicsComprehensive analysis of miRNA expression in T-cell subsets of Rheumatoid arthritis patients and healthy controls reveals defined miRNA signatures of naive and memory Tregs
Disturbed expression of microRNAs (miRNAs) in regulatory T-cells (Tregs) leads to development of autoimmunity in experimental mouse models. However, the miRNA expression signature characterizing Tregs of autoimmune diseases, such as rheumatoid arthritis (RA) has not been determined yet. Moreover, th...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-50646 | biostudies-arrayexpress
TranscriptomicsAgo2 associated gene transcripts in two Hodgkin lymphoma cell lines
The aim of the study is to identify miRNA targets in Hodgkin lymphoma cell lines. By immunoprecipitation of wild type Ago2, it is expected to pull down the Ago2 associated gene transcripts. Through microarray analysis, the Ago2 associated gene transcripts identified are expected to be miRNA targets....
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-14409 | biostudies-arrayexpress
TranscriptomicsAge associated differences in miRNA signatures are restricted to CD45RO negative T cells and are associated with changes in the cellular composition, activation and cellular ageing
MicroRNAs (miRNAs) have emerged as important players in the regulation of T-cell functionality. However, comprehensive insight into the extent of age-related miRNA changes in T cells is lacking. We established miRNA expression patterns of CD45RO- naïve and CD45RO+ memory T-cell subsets isolated from...
ORGANISM(S): Homo sapiens 
2015-05-23 | E-GEOD-69191 | biostudies-arrayexpress
TranscriptomicsExperimental identification of apoptosis-associated miR-21 target genes in Jurkat T-cells using a high-throughput experimental approach
MiR-21 is an important suppressor of T-cell apoptosis that is also widely overexpressed in many types of cancers. The exact mechanisms related to the anti-apoptotic effect of miR-21 is not well understood. In this study, we applied AGO2 RNA Immunoprecipitation followed by gene expression profiling (...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-85116 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of untreated and NT-shRNA transduced kidney proximal tubular epithelial cells (PTECs) at day 6 and day 16 after transduction, as well as SETD2-shRNA transduced PTECs at day 25 after transduction.
Primary kidney PTECs gradually became senescesince day 16, but SETD2 depletion prevented PTECs from senescence and maintained their proliferation beyond their limited dividing capacity. Transcriptional profiling of human PTECs, with comparing of non-senescent PTECs (PTECs-day 6), senescent PTECs (PT...
ORGANISM(S): Homo sapiens 
2016-01-09 | E-GEOD-72792 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in cytoplasmic and nuclear fractions of P493-6 B cells with low c-myc expression to assess long noncoding RNA localization
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59478 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify long noncoding RNAs deregulated in Myc-driven B cell lymphoma
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59479 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Myc-regulated long noncoding RNAs in B cells with variable Myc levels
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59477 | biostudies-arrayexpress
TranscriptomicsOverexpression of miR-155 enhances B-cell lymphoma growth by targeting TBRG1
MYC regulates the expression of multiple microRNA (miRNA) genes and defines the Burkitt lymphoma (BL) miRNA signature. Here, we investigate the role of the MYC-regulated miRNAs by gain- and loss-of-function analysis. Overexpression of 5 miRNAs that were significantly downregulated by MYC resulted in...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-64484 | biostudies-arrayexpress
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