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ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
ProteomicsIdentification of different human CD8 T cell subsets by superior cytotoxicity in human T cells
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and pre-select potent killer cells are lacking. Human CD8+ T cells can be divided into IFNGand IL-2 p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012874 | Pride
Human Il2 Ifng Cd8 T cells 
ProteomicsLabel-free analysis of CD8+ T cell subset proteomes supports a progressive differentiation model of virus-specific T cells in humans
Different pathogens trigger naïve T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive this functional specification, we used high resolution, label-free mass spectrometry to measure proteomic differences between the seven largest circulatin...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD004637 | Pride
Human Cd8+ t cells 
ProteomicsTranslational repression of pre-formed cytokine mRNA prevents chronic activation of memory T cells
Memory T cells are critical to protect us from recurring infections. Their instantaneous reactivity to pathogens is empowered by persistent expression of cytokine mRNA. How aberrant protein production of this pre-formed mRNA is prevented in the absence of infection, however, remains unresolved. We s...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-15 | PXD008051 | Pride
Mouse Memory t cells Orbitrap fusion etd 
ProteomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 6 populations ex vivo
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD007744 | Pride
Human Blood Cd4+ t lymphocyte 
ProteomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 2 populations in vitro
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD007745 | Pride
Human Blood Cd4+ t lymphocytes 
ProteomicsDefective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Weibel-Palade bodies (WPBs) are endothelial secretory organelles that contain VWF, P-selectin and CD63. Release of VWF from WPBs is crucial for platelet adhesion during primary hemostasis. Endosomal trafficking of proteins like CD63 to WPBs during maturation is dependent on the AP-3 complex. Mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD011294 | Pride
Endothelial cells Weibel-palade bodies Hps2 Ap3 complex 
ProteomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 5 populations ex vivo
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD005477 | Pride
Human Lfq Cd4+ t cells 
ProteomicsDynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear bloo...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD013785 | Pride
Transcriptomics Proteomics Neutriphils Myeloid differentiation 
ProteomicsParadigm of biased PAR1 activation and inhibition in endothelial cells dissected by phosphoproteomics
Objective: Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of protease-activated receptors (PARs). The predominant thrombin receptor is PAR1 and in endothelial cells (ECs) thrombin dynamically regulates a plethora of phosphorylation events...
ORGANISM(S): Homo sapiens (Human) 
2017-08-22 | PXD004264 | Pride
Endothelial cells Par1-inhibitors Silac Par1 Thrombin Phosphoproteomics 
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