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TranscriptomicsAn alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme
Most available knowledge on fungal arginine metabolism is derived from studies on Saccharomyces cerevisiae, in which arginine catabolism is initiated by releasing urea via the arginase reaction. Orthologs of the S. cerevisiae genes encoding the first three enzymes in the arginase pathway were cloned...
ORGANISM(S): Kluyveromyces lactis 
2014-07-16 | E-GEOD-56060 | biostudies-arrayexpress
TranscriptomicsA Saccharomyces cerevisiae strain with a minimal complement of glycolytic genes reveals strong redundancies in central metabolism
As a result of ancestral whole genome and small-scale duplication events, the genome of Saccharomyces cerevisiaeM-bM-^@M-^Ys, and of many eukaryotes, still contain a substantial fraction of duplicated genes. In all investigated organisms, metabolic pathways, and more particularly glycolysis, are spe...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-06 | E-GEOD-63884 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of BrO, DMGO and GD2 CAR T cells
Diffuse midline glioma (DMG) is a lethal pediatric brain cancer with limited treatment options. We developed a human brainstem organoid model to study H3.3K27M-driven DMG, enabling formation of patient-like tumors with molecular heterogeneity. To characterize this model, we performed a time-course t...
ORGANISM(S): Homo sapiens 
2025-08-28 | E-MTAB-15147 | biostudies-arrayexpress
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