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UnknownDiscovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from Rhodococcus erythropolis.
Not available
S-EPMC11705230 | biostudies-literature
MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
no omics definedTranscription profiling of ovine keratinocytes stimulated with Psoroptes ovis mite antigen
Comparative expression profiles between unstimulated ovine keratinocytes and keratinocytes stimulated with whole mite antigen and whole mite wash in vitro, over a time course of 1, to 48 hours, using the RIGUA custom array (Watkins et al., 2008) and real-time RT-PCR
ORGANISM(S): Ovis aries 
2009-07-01 | E-TABM-592 | biostudies-arrayexpress
UnknownPharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.
Not available
S-EPMC6375702 | biostudies-literature
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
TranscriptomicsA Saccharomyces cerevisiae strain with a minimal complement of glycolytic genes reveals strong redundancies in central metabolism
As a result of ancestral whole genome and small-scale duplication events, the genome of Saccharomyces cerevisiaeM-bM-^@M-^Ys, and of many eukaryotes, still contain a substantial fraction of duplicated genes. In all investigated organisms, metabolic pathways, and more particularly glycolysis, are spe...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-06 | E-GEOD-63884 | biostudies-arrayexpress
UnknownOncological outcomes of planned and unplanned low Hartmann's procedure and restorative low anterior resection for rectal cancer: a population-based cross-sectional study.
Not available
S-EPMC12678588 | biostudies-literature
UnknownAbandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes.
Not available
S-EPMC10739079 | biostudies-literature
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