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UnknownRare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Background

We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the de...
S-EPMC10074346 | biostudies-literature
UnknownLack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently repor...
S-EPMC11215417 | biostudies-literature
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