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UnknownThe Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.

Introduction

The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesi...
S-EPMC6465616 | biostudies-literature
UnknownNetwork impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke.

Background

Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk pre...
S-EPMC9079101 | biostudies-literature
UnknownRaising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe.

Background

Optimization of antimicrobial stewardship is key to tackling antimicrobial resistance, which is exacerbated by overprescription of antibiotics in pediatric emergency departments (EDs). We described patterns of empiric antibiotic use in European EDs and characterized appropriatenes...
S-EPMC10954344 | biostudies-literature
UnknownFebrile illness in high-risk children: a prospective, international observational study.
To assess and describe the aetiology and management of febrile illness in children with primary or acquired immunodeficiency at high risk of serious bacterial infection, as seen in emergency departments in tertiary hospitals. Prospective data on demographics, presenting features, investigations, mic...
S-EPMC9899189 | biostudies-literature
UnknownRelationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study.

Background

The PERFORM study aimed to understand causes of febrile childhood illness by comparing molecular pathogen detection with current clinical practice.

Methods

Febrile children and controls were recruited on presentation to hospital in 9 European countries 2016-2020. Each child...
S-EPMC10405323 | biostudies-literature
UnknownImpact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens.
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic ...
S-EPMC10384227 | biostudies-literature
UnknownImmunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions.

Importance

The upsurge in invasive disease caused by Streptococcus pyogenes among children reported in several European countries during 2022 to 2023 has not been fully explained.

Objective

To evaluate whether changes in the circulation of common respiratory pathogens associated with ...
S-EPMC12529189 | biostudies-literature
UnknownGenomic investigations of unexplained acute hepatitis in children.
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparat...
S-EPMC10170458 | biostudies-literature
UnknownMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found ...
S-EPMC5968830 | biostudies-literature
UnknownCrop pests and predators exhibit inconsistent responses to surrounding landscape composition.
The idea that noncrop habitat enhances pest control and represents a win-win opportunity to conserve biodiversity and bolster yields has emerged as an agroecological paradigm. However, while noncrop habitat in landscapes surrounding farms sometimes benefits pest predators, natural enemy responses re...
S-EPMC6099893 | biostudies-literature
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