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ProteomicsRetrospective longitudinal monitoring of multiple myeloma patients by mass spectrometry using archived serum protein electrophoresis gels and de novo sequence analysis
M-proteins are antibody molecules produced by a clone of Multiple Myeloma cells. Thus, they are used as a disease activity marker. Traditionally, serum protein electrophoresis gels (SPEP) are used to quantify M-proteins. While effective for diagnostics, sensitivity of SPEP is limited. Here, we demon...
ORGANISM(S): Homo Sapiens 
2022-08-10 | PXD034406 | panorama
ProteomicsOnline electrochemical reduction of both inter- and intramolecular disulfide bridges in immunoglobulins
Cysteine disulfide bridges can be reduced by chemical methods, like an incubation with DTT. However, reduction with an electrochemical method has also been demonstrated. Electrochemical reduction can be implemented online, after LC separation and before mass spectrometry. For the study of antibody m...
ORGANISM(S): Homo sapiens (Human) 
2022-05-27 | PXD021649 | Pride
Electrochemical reduction  disulfide  top-down  antibody 
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