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ProteomicsPlasma proteomics identifies molecular subtypes in sepsis
Background The heterogeneity of sepsis represents a major problem for the development of personalized sepsis therapies. Thus, sepsis subtyping emerged as an important tool to approach this problem, but little progress was made due to insufficient molecular insights. Modern proteomics techniques allo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD064125 | Pride
Machine learning Precision medicine Subclasses Plasma Hierarchical clustering Sepsis Clinical routine data 
ProteomicsMachine learning identifies clinical sepsis phenotypes that translate to the plasma proteome
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
Mass spectrometry Precision medicine Artificial intelligence Plasma Cluster analysis 
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