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TranscriptomicsAdenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs
We used transgenic mouse embryos that are deficient in the two enzymatically active RNA editing enzymes ADAR1 and ADAR2 to compare relative frequencies but also sequence composition of mature miRNAs in these genetically modified backgrounds to wild-type mice by Illumina next gen sequencing. Deficien...
ORGANISM(S): Mus musculus 
2012-02-02 | E-GEOD-34626 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [RNA-Seq]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61066 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [gene expression]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61067 | biostudies-arrayexpress
UnknownUnifying the global phylogeny and environmental distribution of ammonia-oxidising archaea based on amoA genes.
Not available
S-EPMC5904100 | biostudies-literature
TranscriptomicsSimultaneous RNA-seq of bone marrow derived dendritic cells from Mus Musculus C57BL/6 cocultured with Candida albicans strain SC5314 over a 2 hour infection time course
Bone marrow derived dendritic cells from Mus Musculus were cocultured with Candida albicans at a target ratio of 1:1 between 0 and 120 min and samples were collected every 30 minutes.
ORGANISM(S): Mus Musculus 
2013-06-18 | E-MTAB-595 | biostudies-arrayexpress
TranscriptomicsA-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2alpha [gene expression]
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1, lamin A/C also localizes throughout the nucleus, where it associates with the chromatin-binding protein lamina-associated polype...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-70148 | biostudies-arrayexpress
GenomicsA-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2alpha [ChIP-Seq]
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs). In contrast to Lamin B11, lamin A/C also localizes throughout the nucleus, where it associates with the chromatin-binding protein lamina-associated polyp...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-70147 | biostudies-arrayexpress
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