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E-GEOD-14226

ABSTRACT: Transcription profiling by array of mammary gland tissues from Hunk (a novel SNF1/AMPK-related protein kinase) knockout and wild type controls

OTHER RELATED OMICS DATASETS IN: PRJNA111263

PROVIDER: E-GEOD-14226 | ExpressionAtlas | 2014-07-09

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-14226-analysis-methods.tsv	Tabular
	E-GEOD-14226-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-14226-configuration.xml	Xml
	E-GEOD-14226-percentile-ranks.tsv	Tabular
	E-GEOD-14226.condensed-sdrf.tsv	Tabular

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2009-12-31 | GSE14226 | GEO

Project description:We previously identified a novel SNF1/AMPK-related protein kinase, Hunk, from a mammary tumor arising in an MMTV-neu transgenic mouse. The function of this kinase is unknown. Using targeted deletion in mice, we now demonstrate that Hunk is required for the metastasis of c-myc-induced mammary tumors, but is dispensable for normal development. Reconstitution experiments revealed that Hunk is sufficient to restore the metastatic potential of Hunk-deficient tumor cells, as well as defects in migration and invasion, and does so in a manner that requires its kinase activity. Consistent with a role for Hunk in the progression of human cancers, the human homologue of Hunk is overexpressed in aggressive subsets of carcinomas of the ovary, colon, and breast. In addition, a murine gene expression signature that distinguishes Hunk-wild type from Hunk-deficient mammary tumors predicts clinical outcome in women with breast cancer. Together, these findings establish a role for Hunk in metastasis and an in vivo function for this kinase. Hunk-deficient animals were crossed to mice harboring an MMTV-c-myc transgene (Leder et al., 1986). Hunk heterozygous, MMTV-c-myc mice were backcrossed to Hunk heterozygous animals. MMTV-c-myc female animals of each Hunk genotype were mated twice, then monitored twice weekly for mammary tumors. Mice possessing tumors with a maximum diameter of 20 mm were sacrificed and organs were examined at necropsy. Tumor nodules were identified by examination of organs through a Leica Wild MZ8 dissection microscope.

2009-12-31 | E-GEOD-14226 | biostudies-arrayexpress

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