E-GEOD-33827
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA148199
PROVIDER: E-GEOD-33827 | ExpressionAtlas | 2025-01-24
REPOSITORIES: ExpressionAtlas
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| E-GEOD-33827-analysis-methods.tsv | Tabular | |||
| E-GEOD-33827-atlasExperimentSummary.Rdata | Rdata | |||
| E-GEOD-33827-configuration.xml | Xml | |||
| E-GEOD-33827-percentile-ranks.tsv | Tabular | |||
| E-GEOD-33827.condensed-sdrf.tsv | Tabular |
Items per page: 5 1 - 5 of 48 |
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2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
Project description:Expression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
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Project description:Expression data from MDA-MB-231 cells treated with vehicle or YW3-56
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Project description:Expression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
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Project description:Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of cancer cell lines are sensitive to Smac mimetics used as single agents and these cell lines are at risk of developing drug resistance to Smac mimetics. Thus, it is important to understand the molecular mechanisms underlying intrinsic and acquired resistance of cancer cells to Smac mimetics in order to develop effective therapeutic strategies to overcome or prevent Smac mimetic resistance. We established Smac mimetic resistant sublines derived from MDA-MB-231 breast cancer cells, which exhibit exquisite sensitivity to the Smac mimetic SM-164, and used microarrays to detail the global programme of gene expression underlying SM-164 resistance in MDA-MB-231 cells and identified differentially expressed genes in SM-164-resistant and -sensitive MDA-MB-231 cells.
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