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E-GEOD-37209

ABSTRACT: Expression data from Paneth cells isolated from mice on calorie restricted or ad libitum diet

OTHER RELATED OMICS DATASETS IN: PRJNA158971

PROVIDER: E-GEOD-37209 | ExpressionAtlas | 2015-09-28

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-37209-analysis-methods.tsv	Tabular
	E-GEOD-37209-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-37209-configuration.xml	Xml
	E-GEOD-37209-percentile-ranks.tsv	Tabular
	E-GEOD-37209.condensed-sdrf.tsv	Tabular

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Project description:In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood. We have used a mouse model of low birth weight generated through 50% food restriction of mouse dams during the third week of gestation. We have studied in utero food restricted offspring and control offspring that were not food restricted in utero in both the ad libitum and calorie restricted states. Gene expression profiling was performed on tibialis anterior muscle from 8 mice per group, pooled in pairs.

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Expression data from Paneth cells isolated from mice on calorie restricted or ad libitum diet

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