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E-GEOD-39803

ABSTRACT: Transcription profiling by array of mouse bone marrow cells transfected with miR 142-3p mimic oligo

OTHER RELATED OMICS DATASETS IN: PRJNA171744PRJNA171837

PROVIDER: E-GEOD-39803 | ExpressionAtlas | 2015-11-05

REPOSITORIES: ExpressionAtlas

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Mus musculus

Project description:Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

| PRJNA171744 | ENA

Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

Project description:Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describe that miR-142-3p down-regulation directs macrophage differentiation and determines the acquisition of their immunosuppressive function in cancer. Enforced miR over-expression impaired monocyte to macrophage transition both in vitro and in vivo. Conversely, forced miR down-regulation promoted the generation of immunosuppressive macrophages even during G-CSF-induced granulocytic differentiation. To identify how miR-142-3p regulates MDSC generation and activity, we analyze the gene expression of BM cultures transfected with either CTRL- or miR 142-3p mimic oligo -transfected before four days GM-CSF and IL-6 treatment. Keywords: Expression profiling by array

2015-07-23 | GSE39803 | GEO

Mouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.

2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress

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RNA-seq analysis of mouse bone marrow-derived macrophages overexpressing miR-204-3p

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microRNA array of SH-SY5Y cells

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mmu-miR-15a-3p activity in mouse cells

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Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition

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2017-01-25 | GSE81370 | GEO

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