Transcriptomics

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Transcription profiling of adipose tissue and skeletal muscle from non-obese women before and after calorie restriction, resveratrol or placebo treatment


ABSTRACT: Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in non-obese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in non-obese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation was well-tolerated and increased plasma resveratrol concentration without adverse effects, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically-labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, Sirt1, Nampt, and Pgc-1α, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have metabolic effects in non-obese women. We compared gene expression profile in subcutaneous abdominal adipose tissue and skeletal muscle (vastus lateralis) biopsy samples obtained from non-obese people before and after 1) placebo (PLC), 2) resveratrol (RES), and 3) calorie restriction (CR) intervention.

REANALYSIS of: E-GEOD-41168

ORGANISM(S): Homo sapiens  

PROVIDER: E-GEOD-41168 | ExpressionAtlas | 2020-04-03

REPOSITORIES: ExpressionAtlas

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Publications

Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance.

Yoshino Jun J   Conte Caterina C   Fontana Luigi L   Mittendorfer Bettina B   Imai Shin-ichiro S   Schechtman Kenneth B KB   Gu Charles C   Kunz Iris I   Rossi Fanelli Filippo F   Patterson Bruce W BW   Klein Samuel S  

Cell metabolism 20121025 5


Resveratrol has been reported to improve metabolic function in metabolically abnormal rodents and humans, but it has not been studied in nonobese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in nonobese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not chan  ...[more]

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