Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance

ABSTRACT: Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in non-obese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in non-obese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation was well-tolerated and increased plasma resveratrol concentration without adverse effects, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically-labeled tracer infusions, demonstrated that resveratrol did not incre

ORGANISM(S): Homo sapiens

SUBMITTER: C. Charles Gu 

PROVIDER: E-GEOD-41168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress