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E-GEOD-42768

ABSTRACT: Transcription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis

OTHER RELATED OMICS DATASETS IN: PRJNA183090

PROVIDER: E-GEOD-42768 | ExpressionAtlas | 2014-10-17

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-42768-analysis-methods.tsv	Tabular
	E-GEOD-42768-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-42768-configuration.xml	Xml
	E-GEOD-42768-percentile-ranks.tsv	Tabular
	E-GEOD-42768.condensed-sdrf.tsv	Tabular

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Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

Project description:The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphate (DSS) to mimic the relapsing nature of the disease. We used whole gene expression arrays to study differences in colonic gene expression levels between acute and more chronic DSS colitis, Acute and chronic relapsing colonic inflammation was induced in C57BL6 female mice using several cycles of exposure to DSS in drinking water, followed by recovery phases. Total RNA, extracted from snap frozen colon from five mice per condition was used to analyze mRNA expression via Affymetrix Mouse Gene 1.0 ST arrays.

2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress

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Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

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Mus musculus

Project description:Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

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The effect of new probiotic mixture in DSS (dextran sulphate sodium) – induced colitis mouse model

Project description:The current study was designed to clarify signalling pathways and assess possible beneficial effect of new probiotic mixture in DSS (dextran sulphate sodium) – induced colitis mouse model. Manipulation of intestinal microbiota with probiotics represents a promising alternative or adjunct therapy in gastrointestinal disorders and inflammation. RNA extracted from the middle part of colon tissue from ~11 weeks female C57BL/6JOlaHsd mouse strain was used for examination of the global gene expression using Affymetrix GeneChip Mouse Gene 2.0 ST microarrays.

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Project description:Background & Aims: Dextran sulphate sodium (DSS) induced colitis in rats is one of the most widely used models of inflammatory bowel disease. Animal models can provide new insights into the pathogenesis of intestinal inflammation, which is still unknown. We have performed a genomic analysis of the DSS rat colitis including an acute and a recovery phase. Methods: Expression profile of 6 control rats were compared with colitic rats at day 1 every other day until day 23 after DSS treatment using the GeneChip Rat Genome 230 2.0 Array (Affymetrix). Functional and pathways analysis were made with the differentially expressed genes. Keywords: Time course and differentially expressed genes analysis

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