Transcriptomics

Dataset Information

9

Transcriptome profile of subcutaneous adipocytes isolated from obese vs. lean postmenopausal women


ABSTRACT: Adipocytes isolated from lean and obese postmenopausal women with no significant differences in metabolic syndrome parameters demonstrate changes in multiple inflammatory, metabolic and structural gene families. Purified adipocyte samples were isolated from subcutaneous adipose tissue surgical biopsies of 7 obese (BMI>30) and 7 lean (BMI<25) postmenoposal women and gene expression was quantified with Agilent-014850, 4X44K human whole genome platform arrays (GPL6480)

REANALYSIS of: E-GEOD-44000

ORGANISM(S): Homo sapiens  

PROVIDER: E-GEOD-44000 | ExpressionAtlas | 2015-07-10

REPOSITORIES: ExpressionAtlas

Dataset's files

Source:
Action DRS
E-GEOD-44000-analysis-methods.tsv Tabular
E-GEOD-44000-atlasExperimentSummary.Rdata Rdata
E-GEOD-44000-configuration.xml Xml
E-GEOD-44000-percentile-ranks.tsv Tabular
E-GEOD-44000.condensed-sdrf.tsv Tabular
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Publications


Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. Microarray analysis of primary adipocytes revealed that multiple genes involved in MHCII antigen processing and presentation increased in obese women. In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling incre  ...[more]

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