Dataset Information


Transcriptome profile of subcutaneous adipocytes isolated from obese vs. lean postmenopausal women

ABSTRACT: Adipocytes isolated from lean and obese postmenopausal women with no significant differences in metabolic syndrome parameters demonstrate changes in multiple inflammatory, metabolic and structural gene families. Purified adipocyte samples were isolated from subcutaneous adipose tissue surgical biopsies of 7 obese (BMI>30) and 7 lean (BMI<25) postmenoposal women and gene expression was quantified with Agilent-014850, 4X44K human whole genome platform arrays (GPL6480)


ORGANISM(S): Homo sapiens  

PROVIDER: E-GEOD-44000 | ExpressionAtlas | 2015-07-10

REPOSITORIES: ExpressionAtlas

Dataset's files

Action DRS
E-GEOD-44000-analysis-methods.tsv Tabular
E-GEOD-44000-atlasExperimentSummary.Rdata Rdata
E-GEOD-44000-configuration.xml Xml
E-GEOD-44000-percentile-ranks.tsv Tabular
E-GEOD-44000.condensed-sdrf.tsv Tabular
Items per page:
1 - 5 of 48
altmetric image


Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. Microarray analysis of primary adipocytes revealed that multiple genes involved in MHCII antigen processing and presentation increased in obese women. In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling incre  ...[more]

Similar Datasets

2013-02-02 | E-GEOD-44000 | ArrayExpress
2016-06-15 | E-GEOD-75091 | ArrayExpress
2013-10-28 | E-GEOD-51760 | ArrayExpress
2015-01-01 | S-EPMC4439568 | BioStudies
2010-06-20 | E-GEOD-15524 | ArrayExpress
1000-01-01 | S-EPMC6244201 | BioStudies
1000-01-01 | S-EPMC4499111 | BioStudies
2011-01-01 | S-EPMC6444514 | BioStudies
2013-07-04 | E-GEOD-48521 | ArrayExpress
2014-01-01 | S-EPMC3928248 | BioStudies