Project description:We report the application of Illumina small RNA sequencing to normal human skin, as well as uninvolved and involved psoriatic skin. By obtaining over 600 million qualified reads from 20 healthy controls and 47 psoriasis biopsies (uninvolved/involved), we have generated a complete small RNA profile in normal and diseased human skin, with particular emphasis on miRNAs. We report the discovery of 284 putative novel miRNAs as well as 98 differentially expressed miRNAs in psoriatic skin. miRNA discovery and expression profiling in 67 normal and psoriatic human skin biopsies

2011-08-19 | E-GEOD-31037 | biostudies-arrayexpress

Sweat proteomic of cystic fibrosis patients

Project description:Sweat plays a crucial role in thermo-regulation and skin health and potentially antimicrobial defense. Its composition is highly dynamic and its homeostasis involves a fine tuning of metabolic pathways. In-depth profiling of sweat protein composition will increase our understanding of skin disorders. Cystic Fibrosis (CF) is associated with high NaCl sweat concentration due to the absence of the CFTR protein. Patients with CF (pwCF) often display aquagenic palmoplantar keratodermia, a rare skin disorder characterized by skin wrinkling with oedema and whitish papules on the palms and/or soles, the pathophysiology of which is unknown. We report an in-depth analysis of the human sweat proteome of pwCF patients in comparison with that of healthy subjects (S).

2023-03-11 | PXD032894 | Pride

Whole genome transcriptional profiling of reconstructed human epidermis treated with 5% lactic acid compare to negative control as treated with water

Project description:Lactic acid is used to check skin sensitivity of human. However transcriptional profiling has not been done yet. This study was targeted to understand the transcriptional changes occur in human skin upon treatment with lactic acid.

2019-06-07 | E-MTAB-6935 | biostudies-arrayexpress

Homo sapiens

Project description:Gene expression profiling of sensitive skin

| PRJNA210355 | ENA