Genomics,Multiomics

Dataset Information

3

Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects


ABSTRACT: Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Experiment Overall Design: RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.

REANALYSIS of: E-GEOD-5390

OTHER RELATED OMICS DATASETS IN: PRJNA96183

ORGANISM(S): Homo sapiens  

PROVIDER: E-GEOD-5390 | ExpressionAtlas | 2015-07-27

REPOSITORIES: ExpressionAtlas

Dataset's files

Source:
Action DRS
E-GEOD-5390-analysis-methods.tsv Tabular
E-GEOD-5390-atlasExperimentSummary.Rdata Rdata
E-GEOD-5390-configuration.xml Xml
E-GEOD-5390-percentile-ranks.tsv Tabular
E-GEOD-5390.condensed-sdrf.tsv Tabular
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Publications

Gene expression profiling in the adult Down syndrome brain.

Lockstone HE   Harris LW   Swatton JE   Wayland MT   Holland AJ   Bahn S  

Genomics 20071022 6


The mechanisms by which trisomy 21 leads to the characteristic Down syndrome (DS) phenotype are unclear. We used whole genome microarrays to characterize for the first time the transcriptome of human adult brain tissue (dorsolateral prefrontal cortex) from seven DS subjects and eight controls. These data were coanalyzed with a publicly available dataset from fetal DS tissue and functional profiling was performed to identify the biological processes central to DS and those that may be related to  ...[more]

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