Transcriptomics,Multiomics

Dataset Information

6

Transcription profiling by array of chicken anterior and posterior wing bud thirds from stage HH24 normal and talpid3 mutant embryos


ABSTRACT: Relative levels of RNA transcripts were compared between anterior and posterior wing bud thirds from stage HH24 normal and talpid3 mutant chicken embryos using chicken Affymetrix chips. Data collected with Affymetrix scanner was normalized using the Plier algorithm within the expression console package from Affymetrix and log2 transformed. 5 replicates of anterior third normal wing buds, 4 replicates of posterior third of normal wing buds and 4 replicates each of anterior and posterior thirds of talpid3 wing buds at stage HH24 were examined.

REANALYSIS of: E-MTAB-309

ORGANISM(S): Gallus gallus  

PROVIDER: E-MTAB-309 | ExpressionAtlas | 2015-11-02

REPOSITORIES: ExpressionAtlas

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Publications

Identification of genes downstream of the Shh signalling in the developing chick wing and syn-expressed with Hoxd13 using microarray and 3D computational analysis.

Bangs Fiona F   Welten Monique M   Davey Megan G MG   Fisher Malcolm M   Yin Yili Y   Downie Helen H   Paton Bob B   Baldock Richard R   Burt David W DW   Tickle Cheryll C  

Mechanisms of development 20100812 9-12


Sonic hedgehog (Shh) signalling by the polarizing region at the posterior margin of the chick wing bud is pivotal in patterning the digits but apart from a few key downstream genes, such as Hoxd13, which is expressed in the posterior region of the wing that gives rise to the digits, the genes that mediate the response to Shh signalling are not known. To find genes that are co-expressed with Hoxd13 in the posterior of chick wing buds and regulated in the same way, we used microarrays to compare g  ...[more]

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