Transcriptomics

Dataset Information

0

Identification of chicken Interferon Stimulated Genes (ISGs) using Affymetrix GeneChip Chicken Genome Arrays


ABSTRACT: Recombinant chicken IFN1 was prepared as previously reported (Laidlaw et al, 2013) and was added in chicken embryo fibroblasts to a final concentration of 1000 U/ml. Confluent cells were treated with chicken IFNa or mock treated and incubated for six hours before harvesting. The experiment was repeated in triplicate with three different batches of CEFs.

REANALYSIS of: E-MTAB-3711

ORGANISM(S): Gallus gallus  

PROVIDER: E-MTAB-3711 | ExpressionAtlas | 2015-07-14

REPOSITORIES: ExpressionAtlas

Dataset's files

Source:
Action DRS
E-MTAB-3711-analysis-methods.tsv Tabular
E-MTAB-3711-atlasExperimentSummary.Rdata Rdata
E-MTAB-3711-configuration.xml Xml
E-MTAB-3711-percentile-ranks.tsv Tabular
E-MTAB-3711.condensed-sdrf.tsv Tabular
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Publications

Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α).

Giotis Efstathios S ES   Robey Rebecca C RC   Skinner Natalie G NG   Tomlinson Christopher D CD   Goodbourn Stephen S   Skinner Michael A MA  

Veterinary research 20160805 1


Viruses that infect birds pose major threats-to the global supply of chicken, the major, universally-acceptable meat, and as zoonotic agents (e.g. avian influenza viruses H5N1 and H7N9). Controlling these viruses in birds as well as understanding their emergence into, and transmission amongst, humans will require considerable ingenuity and understanding of how different species defend themselves. The type I interferon-coordinated response constitutes the major antiviral innate defence. Although  ...[more]

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