Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-3938

ABSTRACT: Transcription profiling by high throughput sequencing of pancreatic islets from R299Q AMPK gamma 2 knock-in mice

PROVIDER: E-MTAB-3938 | ExpressionAtlas | 2019-05-14

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling by high throughput sequencing of pancreatic islets from R299Q AMPK gamma 2 knock-in mice

Project description:Transcription profiling by high throughput sequencing of pancreatic islets from R299Q AMPK gamma 2 knock-in mice

| PRJEB11183 | ENA

Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

Project description:Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

| PRJEB7122 | ENA

Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

Project description:RNA-Seq was performed on pancreatic islets from four transgenic mouse strains affecting LKB1 and AMPK. A conditional LKB1 knockout strain was generated. Double conditional knockouts for AMPK alpha1 and AMPK alpha2 were also generated. These conditional strains were crossed with RIP-Cre (driven by rat insulin promoter) or Ins1-Cre mice to generate LKB1 knockout and AMPK double knockout strains.

2014-10-25 | E-MTAB-2791 | biostudies-arrayexpress

E-MTAB-2791

Project description:Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

2019-05-14 | E-MTAB-2791 | ExpressionAtlas

Ghrelin deletion and conditional ghrelin-cell ablation increase pancreatic islet size in mice

Project description:We utilized single cell sequencing of FACS sorted cells from pancreatic islets of wildtype and ghrelin knock out mice to understand the effects of ghrelin deletion on gene expression profiles of various islet cells.

2023-11-06 | GSE244390 | GEO

Expression profiling of pancreatic islets in Tcf1 knock out mice

Project description:Expression profiling of pancreatic islets in Tcf1 knock out mice Keywords: repeat sample serie

2005-12-08 | GSE3544 | GEO

LPS induced CXCL10 chemokine production via IFN- α receptor and toll-like receptor 4 signalling

Project description:CXCL10 is a chemokine induced by IFN-γ and implicated in the pathogenesis of type 1 diabetes (T1D). It attracts IFN-γ-producing T cells to the pancreatic islets, forming a positive feed-forward loop where T cells induce CXCL10 and attract themselves, but it is unclear what attracts the first IFN-γ-producing T cells in islets. Lipopolysaccharide induced CXCL10 production in cultured islets of nonobese diabetic (NOD) mice, and the lack of its inhibition in islets from NOD mice deficient for RAG1 or IFN-g receptor revealed its dissociation from the requirement of T cells and IFN-γ. To further investigate the mechanism of LPS induced CXCL10 production, the gene expression profile of pancreatic beta cells after culture of whole islets in LPS was analysed. Overall a gene expression signature of cytokine signalling, particularly by type I IFNs and TLR4 was upregulated after culture of islets in LPS.

2023-03-07 | GSE218698 | GEO

Role of IGF2R in beta cells

Project description:RNA-seq data of isolated pancreatic islets of one-year-old wild type and IGF2 receptor knock out mice.

2024-01-10 | GSE252585 | GEO

RNA-Seq of pancreatic islets derived from mice fed a long-term high-fat diet against chow-fed controls

Project description:We report the application of next-generation sequencing technology for high-throughput profiling of H3K27ac and transcriptome analysis in pancreatic islets derived from C57Bl/6 mice fed a high-fat diet. We find genomic regions showing change in acetylation of histone H3K27 in response to long-term HFD feeding, which was significantly associated with differential gene expression. Furthermore, increased H3K27ac showed a distinctive genomic distribution surrounding proximal-promoter regions. This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cells under various environments.

2018-10-02 | E-MTAB-6718 | biostudies-arrayexpress

H3K27ac ChIP-Seq of pancreatic islets derived from mice fed a long-term high-fat diet (HFD) against chow-fed controls

Project description:We report the application of next-generation sequencing technology for high-throughput profiling of H3K27ac and transcriptome analysis in pancreatic islets derived from C57Bl/6 mice fed a high-fat diet. We find genomic regions showing change in acetylation of histone H3K27 in response to long-term (26 weeks) HFD feeding, which was significantly associated with differential gene expression. Furthermore, increased H3K27ac showed a distinctive genomic distribution surrounding proximal-promoter regions. This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cells under various environments.

2018-10-02 | E-MTAB-6719 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data