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E-MTAB-6256

ABSTRACT: RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

PROVIDER: E-MTAB-6256 | ExpressionAtlas | 2020-07-23

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-6256-analysis-methods.tsv	Tabular
	E-MTAB-6256-analytics.tsv	Tabular
	E-MTAB-6256-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-6256-configuration.xml	Xml
	E-MTAB-6256-g1_g2-mvaPlot.png	Other

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RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

Project description:RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

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RNA-seq of liver from pigs divergent in feed efficiency highlights shifts in macronutrients metabolism, hepatic growth and immune response

Project description:Liver is a metabolically complex organ that influences nutrient partitioning and potentially modulates the efficiency of converting energy acquired from macronutrients ingestion into a muscle and/or adipose tissue (referred to as feed efficiency, FE). The objective of this study was to sequence the hepatic tissue transcriptome of pigs divergent for FE and identify relevant biological processes that underpin the differences in liver phenotypes and FE.

2019-02-11 | E-MTAB-6256 | biostudies-arrayexpress

Strategies towards improved feed efficiency in pigs comprise molecular shifts in hepatic lipid and carbohydrate metabolism

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E-MTAB-6255

Project description:RNA-seq of adipose tissue from pigs divergent in feed efficiency reveals variations in adipose growth, extracellular matrix formation, lipid metabolism and immune response

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Project description:RNA-seq of liver tissues in divergent feed efficiency DLY pigs

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RNA-seq of adipose tissue from pigs divergent in feed efficiency reveals variations in adipose growth, extracellular matrix formation, lipid metabolism and immune response

Project description:RNA-seq of adipose tissue from pigs divergent in feed efficiency reveals variations in adipose growth, extracellular matrix formation, lipid metabolism and immune response

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RNA-seq of adipose tissue from pigs divergent in feed efficiency reveals variations in adipose growth, extracellular matrix formation, lipid metabolism and immune response

Project description:Feed efficiency (FE) is an indicator of efficiency in converting energy, attained from macronutrient ingestion, into tissue. Adipose tissue, besides being a master regulator of systemic lipid storage, is also an active endocrine organ that communicates with skeletal muscle, liver and brain to influence appetite, lipid & glucose metabolism and energy homeostasis. Adipose tissue is hypothesised to play a vital part in regulation of FE. The objective of the present study was to sequence the subcutaneous adipose tissue transcriptome in FE-divergent pigs (n=16) and identify relevant biological processes underpinning observed differences in FE.

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RNA-seq and ATAC-seq data from pig jejunum with high and low feed efficiency

Project description:Feed efficiency (FE) is a crucial trait in pig production that influences both economic viability and environmental sustainability. The jejunum, an essential organ for nutrient absorption, plays a significant role in determining FE by affecting how pigs process and utilize feed. To explore the genetic and regulatory mechanisms behind FE, we conducted an integrative multi-omics study using RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) on pigs with high and low FE. By comparing gene expression and chromatin accessibility profiles in the jejunum, we identified key differentially expressed genes (DEGs) and differentially accessible regions (DARs) associated with lipid metabolism and immune function, both of which are critical pathways for efficient growth. Notably, we identified transcription factors such as GATA4 and EHF and genes like SCARB1 and GRXCR1 that may play regulatory roles in FE. Our findings provide novel insights into the molecular mechanisms governing FE in pigs, offering potential targets for genetic selection and nutritional interventions to enhance feed efficiency and sustainability in pig production.

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Project description:in vivo microarray study of transcriptional changes of ileum (mucosa) obtained from pigs divergent in feed efficiency

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