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E-MTAB-9101

ABSTRACT: RNA-seq analysis of kidney and jejunum of German Landrace sows fed high, medium and low level of dietary phosphorus

PROVIDER: E-MTAB-9101 | ExpressionAtlas | 2020-07-20

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-9101-analysis-methods.tsv	Tabular
	E-MTAB-9101-analytics.tsv	Tabular
	E-MTAB-9101-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-9101-configuration.xml	Xml
	E-MTAB-9101-g5_g1-mvaPlot.png	Other

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RNA-seq analysis of kidney and jejunum of German Landrace sows fed high, medium and low level of dietary phosphorus

Project description:RNA-seq analysis of kidney and jejunum of German Landrace sows fed high, medium and low level of dietary phosphorus

| PRJEB38415 | ENA

RNA-seq analysis of kidney and jejunum of German Landrace sows fed high, medium and low level of dietary phosphorus

Project description:A deeper understanding of molecular mechanisms of phosphorus (P) utilization of sows during pregnancy and lactating could help to reduce the environmental impact. Kidney and small intestine play an important role in phosphorus utilization. The aim of this study was to investigate 1) whether sows fed with a dietary P content that is below or above current recommendations are capable to maintain mineral homeostasis during the reproduction cycle and 2) which endogenous mechanisms are retrieved in kidney and jejunum using RNA-seq analysis. Nulliparous gilts were fed iso-energetic diets with recommended (M), reduced (L), or high (H) amounts of mineral P supplements throughout gestation and lactation periods.

2020-08-25 | E-MTAB-9101 | biostudies-arrayexpress

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Project description:Gene expression analysis of subcutaneous adipose tissue in mice fed with a low-protein/high carbohydrate diet

2020-07-20 | E-MTAB-8850 | ExpressionAtlas

Transcriptional responsen of phosphorus (re-)absorbing organs to diets varying in phosphorus content in pigs (low-intake; medium intake; high-intake)

Project description:in vivo microarray study of transcriptional changes in porcine jejunum, colon and kidney due to dietary intake of phosphorus

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Gene profiles of HUVECs in different phosphate concentration

Project description:Hyperphosphatemia is an independent risk factor for cardiovascular mortality in chronic kidney disease. High inorganic phosphorus can induce endothelial cell apoptosis, but the exact mechanism is not fully understood. This study addresses this knowledge gap.Microarray analysis was used to identify differentially expressed gene profiles in human umbilical vein endothelial cells (HUVECs) in high phosphate (3.0 mM) normal phosphate (1.0 mM) medium and low phosphate( 0.5mM).

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Project description:Low grade gliomas subtype analysis

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Project description:SWATH analysis of human kidney tissues to generate a digital map representing the proteome of biopsy level clinical samples.

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Effect of a High Phosphorus Diet on Renal Gene Expressions in Rat

Project description:The mechanism by which phosphorus levels are maintained in the body was investigated by analyzing changes in gene expression in the rat kidney following administration of a high-phosphorus diet. Male Wistar rats were fed a high phosphorous (HP) diet containing 1.2% phosphorous, or 0.3% HP as a control, for 24 days. Phosphorous retention was not significantly increased in HP rats, but fractional excretion of phosphorus was significantly increased in the HP group compared to controls, with an excessive amount of the ingested phosphorus being passed through the body. DNA microarray analysis of kidney tissue from both groups revealed changes in gene expression profile induced by a HP diet. Among the genes that were upregulated, gene ontology (GO) terms related to ossification, collagen fibril organization, and inflammation and immune response were significantly enriched. In particular, there was significant upregulation of type IIb sodium-dependent phosphate transporter (NaPi-IIb) in the HP rat kidney compared to control rats. This upregulation was confirmed by in situ hybridization. Discreet signals for NaPi-IIb in both the cortex and medulla of the kidney were apparent in the HP group, while the corresponding signals were much weaker in the control group. Immunohistochemical analysis showed that NaPi-IIb localized to the basolateral side of kidney epithelial cells surrounding the urinary duct in HP rats but not in control animals. These data suggest that NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats.

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E-MTAB-4349

Project description:Gene expression analysis of SDH-deficient immortalized mouse kidney epithelial cells

2016-02-03 | E-MTAB-4349 | ExpressionAtlas

Upregulated Hepatic Lipogenesis from Dietary Sugars Supplies Palmitic Acid to the Developing Brain of Mice fed Low Palmitic Acid from Birth

Project description:Background: Palmitic acid (PAM) can be provided in the diet or synthesized via de novo lipogenesis (DNL) primarily from glucose. Preclinical work on the origin of brain PAM during development is scarce and contrasts results on the origin of adult brain PAM. Here, we utilize naturally occurring carbon isotope ratios (13C/12C; δ13C) and RNA sequencing to uncover the origin of brain PAM, and pathways involved in maintaining brain PAM, respectively, during development. maintaining brain PAM, respectively, during development. Methods: Dams were equilibrated onto diets low (<2%), medium (47%) or high (>95%) in PAM prior to breeding. Dietary PAM was depleted in δ13C, while dietary sugars were enriched. Offspring stayed on the respective dam diet and were euthanized at postnatal day 0, 10, 21, and day 35. Pup liver and brain fatty acids were quantified, after which, tissue δ13C-PAM was measured by compound specific isotope analysis. Day 35 tissue RNA was sequenced on a NovaSeq S4 Flowcell. Results: Although PAM levels in the liver reflected levels of dietary PAM, PAM was maintained in total and individual brain phospholipid fractions across diet groups at all timepoints. Tissue δ13C-PAM was enriched overall and augmented in mice fed low PAM, compared to medium and high PAM suggesting that DNL from dietary sugars maintained the majority of the brain PAM pool. Furthermore, DNL pathways were upregulated in mice fed low compared to high PAM in the liver, but not the brain at day 35. Conclusions: Lipogenesis from dietary sugars maintains the majority of brain PAM during development and is augmented in mice fed low PAM from birth. Importantly, hepatic lipogenesis from dietary sugars determines PAM availability to the developing brain when low in the diet – a compensatory mechanism identified to maintain total brain PAM pools compared to periphery which ultimately suggests an importance of brain PAM regulation during development.

2023-11-08 | GSE225568 | GEO

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