Transcription profiling by array of patients with ASXL1 mutations in cytogenetically normal acute myeloid leukemia
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ABSTRACT:
REANALYSIS of: E-TABM-1208
ORGANISM(S): Homo sapiens
PROVIDER: E-TABM-1208 | ExpressionAtlas | 2015-11-02
REPOSITORIES: ExpressionAtlas
Publications
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.
Metzeler Klaus H KH Becker Heiko H Maharry Kati K Radmacher Michael D MD Kohlschmidt Jessica J Mrózek Krzysztof K Nicolet Deedra D Whitman Susan P SP Wu Yue-Zhong YZ Schwind Sebastian S Powell Bayard L BL Carter Thomas H TH Wetzler Meir M Moore Joseph O JO Kolitz Jonathan E JE Baer Maria R MR Carroll Andrew J AJ Larson Richard A RA Caligiuri Michael A MA Marcucci Guido G Bloomfield Clara D CD
Blood 20111026 26
The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. We analyzed 423 adult patients for ASXL1 mutations, other prognostic gene mutations, and gene-/microRNA-expression profiles. ASXL1 mutations were 5 times more common in older (≥ 60 years) patients (16.2%) than those younger than 60 years ( ...[more]
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