Transcriptomics,Multiomics

Dataset Information

65

Transcription profiling by array of patients with ASXL1 mutations in cytogenetically normal acute myeloid leukemia


ABSTRACT: We studied gene expression profiles from 65 patients with CN-AML, who all had wild-type NPM1 and no FLT3-ITD. We identified an ASXL1 mutation-associated gene expression signature by comparing 26 ASXL1-mutated and 39 ASXL1-wild type patients. Only NPM1 wild type/FLT3-ITD-negative patients were included in this analysis to avoid potential confounding due to the effects of these two mutations on gene expression.

REANALYSIS of: E-TABM-1208

ORGANISM(S): Homo sapiens  

PROVIDER: E-TABM-1208 | ExpressionAtlas | 2015-11-02

REPOSITORIES: ExpressionAtlas

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Publications


The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. We analyzed 423 adult patients for ASXL1 mutations, other prognostic gene mutations, and gene-/microRNA-expression profiles. ASXL1 mutations were 5 times more common in older (≥ 60 years) patients (16.2%) than those younger than 60 years (  ...[more]

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