Ontology highlight
ABSTRACT:
SUBMITTER: Enuo He
PROVIDER: BIOMD0000000077 | BioModels | 2006-11-09
REPOSITORIES: BioModels
American journal of physiology. Endocrinology and metabolism 20000201 2
A mathematical model is developed to investigate the rate of release of luteinizing hormone (LH) from pituitary gonadotropes in response to short pulses of gonadotropin-releasing hormone (GnRH). The model includes binding of the hormone to its receptor, dimerization, interaction with a G protein, production of inositol 1,4, 5-trisphosphate, release of Ca(2+) from the endoplasmic reticulum, entrance of Ca(2+) into the cytosol via voltage-gated membrane channels, pumping of Ca(2+) out of the cytos ...[more]