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Somogyi1990_CaOscillations


ABSTRACT: This model encoded according to the paper Hormone induced Calcium Oscillations in Liver Cells Can Be Explained by a Simple One Pool Model. The values of parameters a and alpha are varioused inorder to simulate results in different situations. For Figure 3A, a=3.5,alpha=1.2 ; Figure 3B, a=3,alpha=5 ; Figure 3C a= 0.95, alpha=1.5; Figure3D, a=1, alpha=5. Keep in mind that the value for the xy axies are arbitrary value. Figures3 in the paper are reproduced by COPASI 4.0.20(development) , and SBMLodeSolver online. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Enuo He  

PROVIDER: BIOMD0000000114 | BioModels | 2007-05-10

REPOSITORIES: BioModels

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Publications

Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model.

Somogyi R R   Stucki J W JW  

The Journal of biological chemistry 19910601 17


Hormone-induced oscillations of the free intracellular calcium concentration are thought to be relevant for frequency encoding of hormone signals. In liver cells, such Ca2+ oscillations occur in response to stimulation by hormones acting via phosphoinositide breakdown. This observation may be explained by cooperative, positive feedback of Ca2+ on its own release from one inositol 1,4,5-trisphosphate-sensitive pool, obviating oscillations of inositol 1,4,5-trisphosphate. The kinetic rate laws of  ...[more]

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