Ontology highlight
ABSTRACT:
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000207 | BioModels | 2008-09-10
REPOSITORIES: BioModels
Annals of the New York Academy of Sciences 19990601
The animal cell cycle is controlled by the periodic variation of two cyclin-dependent protein kinases, cdk1 and cdk2, which govern the entry into the M (mitosis) and S (DNA replication) phases, respectively. The ordered progression between these phases is achieved thanks to the existence of checkpoint mechanisms based on mutual inhibition of these processes. Here we study a simple theoretical model for oscillations in cdk1 and cdk2 activity, involving mutual inhibition of the two oscillators. Ea ...[more]