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Machado2014 - Curcumin production pathway in Escherichia coli


ABSTRACT: Machado2014 - Curcumin production pathway in Escherichia coli This model is described in the article: A kinetic model for curcumin production in Escherichia coli. Machado D, Rodrigues LR, Rocha I. BioSystems 2014 Nov; 125: 16-21 Abstract: Curcumin is a natural compound obtained from turmeric, and is well known for its pharmacological effects. In this work, we design a heterologous pathway for industrial production of curcumin in Escherichia coli. A kinetic model of the pathway is then developed and connected to a kinetic model of the central carbon metabolism of E. coli. This model is used for optimization of the mutant strain through a rational design approach, and two manipulation targets are identified for overexpression. Dynamic simulations are then performed to compare the curcumin production profiles of the different mutant strains. Our results show that it is possible to obtain a significant improvement in the curcumin production rates with the proposed mutants. The kinetic model here developed can be an important framework to optimize curcumin production at an industrial scale and add value to its biomedical potential. This model is hosted on BioModels Database and identified by: BIOMD0000000565. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Daniel Machado  

PROVIDER: BIOMD0000000565 | BioModels | 2015-01-12

REPOSITORIES: BioModels

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Publications

A kinetic model for curcumin production in Escherichia coli.

Machado Daniel D   Rodrigues Lígia R LR   Rocha Isabel I  

Bio Systems 20140916


Curcumin is a natural compound obtained from turmeric, and is well known for its pharmacological effects. In this work, we design a heterologous pathway for industrial production of curcumin in Escherichia coli. A kinetic model of the pathway is then developed and connected to a kinetic model of the central carbon metabolism of E. coli. This model is used for optimization of the mutant strain through a rational design approach, and two manipulation targets are identified for overexpression. Dyna  ...[more]

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