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Queralt2006 - Initiation of mitotic exit by downregulation of PP2A in budding yeast

ABSTRACT: Mathematical model of mitotic exit in budding yeast.

SUBMITTER: Matthieu MAIRE

PROVIDER: BIOMD0000000953 | BioModels | 2020-05-18

REPOSITORIES: BioModels

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Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

Queralt Ethel E Lehane Chris C Novak Bela B Uhlmann Frank F

Cell 20060501 4

After anaphase, the high mitotic cyclin-dependent kinase (Cdk) activity is downregulated to promote exit from mitosis. To this end, in the budding yeast S. cerevisiae, the Cdk counteracting phosphatase Cdc14 is activated. In metaphase, Cdc14 is kept inactive in the nucleolus by its inhibitor Net1. During anaphase, Cdk- and Polo-dependent phosphorylation of Net1 is thought to release active Cdc14. How Net1 is phosphorylated specifically in anaphase, when mitotic kinase activity starts to decline, ...[more]

PMID: 16713564

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