Dataset Information
Thomas2014 - The effect of aspirin resistance on platelet metabolism (constraint-based modelling)
Ontology highlight
ABSTRACT:
SUBMITTER: 
Alex Thomas
PROVIDER: MODEL1401290000 | BioModels | 2005-01-01
REPOSITORIES: BioModels
Publications
Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance.
Scientific reports 20140129
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The network contains enzymes mapping to 403 diseases and 231 FDA approved drugs, alluding to an expansive scope of biochemical transformations that may affect or be affected by disease p ...[more]
