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Mardinoglu2013 - Genome-scale metabolic model (HMR version 1.0) - generic human cell

ABSTRACT: No description

SUBMITTER: Adil Mardinoglu  

PROVIDER: MODEL1402200000 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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Publications

Integration of clinical data with a genome-scale metabolic model of the human adipocyte.

Mardinoglu Adil A   Agren Rasmus R   Kampf Caroline C   Asplund Anna A   Nookaew Intawat I   Jacobson Peter P   Walley Andrew J AJ   Froguel Philippe P   Carlsson Lena M LM   Uhlen Mathias M   Nielsen Jens J  

Molecular systems biology 20130101

We evaluated the presence/absence of proteins encoded by 14 077 genes in adipocytes obtained from different tissue samples using immunohistochemistry. By combining this with previously published adipocyte-specific proteome data, we identified proteins associated with 7340 genes in human adipocytes. This information was used to reconstruct a comprehensive and functional genome-scale metabolic model of adipocyte metabolism. The resulting metabolic model, iAdipocytes1809, enables mechanistic insigh  ...[more]

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