Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1807180001 | BioModels | 2018-07-18
REPOSITORIES: BioModels
Baugh R J RJ Broze G J GJ Krishnaswamy S S
The Journal of biological chemistry 19980201 8
Tissue factor (TF) pathway inhibitor (TFPI) regulates factor X activation through the sequential inhibition of factor Xa and the VIIa.TF complex. Factor Xa formation was studied in a purified, reconstituted system, at plasma concentrations of factor X and TFPI, saturating concentrations of factor VIIa, and increasing concentrations of TF reconstituted into phosphatidylcholine:phosphatidylserine membranes (TF/PCPS) or PC membranes (TF/PC). The initial rate of factor Xa formation was equivalent in ...[more]