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Wu2017 - Murine Bevacizumab PK model


ABSTRACT: This is the first report evaluating the use of fluorescent imaging to determine the pharmacokinetics, lymphatic uptake, and bioavailability of a near-infrared dye-labeled antibody conjugate. Model is encoded by Matthew Roberts and submitted to BioModels by Krishna Tiwari

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: MODEL2003030003 | BioModels | 2020-03-05

REPOSITORIES: BioModels

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Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administration in mice.

Wu Fang F   Tamhane Mitalee M   Morris Marilyn E ME  

The AAPS journal 20120306 2


Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibody bevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration in mice. Fluorescence imaging and enzyme-linked immunosorbent assay (ELISA) assays were developed and validated to measure the concentration of bevacizumab in plasma. The bevacizumab-IRDye conjugate remained predominantly intact in plasma and in lymph node homog  ...[more]

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