Models

Dataset Information

0

Wu2017 - Murine Bevacizumab PK model


ABSTRACT: This is the first report evaluating the use of fluorescent imaging to determine the pharmacokinetics, lymphatic uptake, and bioavailability of a near-infrared dye-labeled antibody conjugate. Model is encoded by Matthew Roberts and submitted to BioModels by Krishna Tiwari

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: MODEL2003030003 | BioModels | 2020-03-05

REPOSITORIES: BioModels

altmetric image

Publications

Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administration in mice.

Wu Fang F   Tamhane Mitalee M   Morris Marilyn E ME  

The AAPS journal 20120306 2


Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibody bevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration in mice. Fluorescence imaging and enzyme-linked immunosorbent assay (ELISA) assays were developed and validated to measure the concentration of bevacizumab in plasma. The bevacizumab-IRDye conjugate remained predominantly intact in plasma and in lymph node homog  ...[more]

Similar Datasets

2020-03-05 | MODEL2003030002 | BioModels
2020-05-06 | MODEL2003180001 | BioModels
2020-03-17 | MODEL2003170002 | BioModels
| 2641945 | ecrin-mdr-crc
2023-12-27 | GSE245658 | GEO
| 2533714 | ecrin-mdr-crc
2020-03-18 | MODEL2003180002 | BioModels
| 20059 | ecrin-mdr-crc
2022-03-06 | GSE197666 | GEO
| PRJEB51223 | ENA