Corral2021 - Interplay between SMAD2 and STAT5A regulating IL-17A/F expression in Th cells.

ABSTRACT: IL-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells but the underlying mechanisms remain unknown. To address this question, a logical model containing 82 components and 136 regulatory links was developed and calibrated with original flow cytometry data using naive CD4+ T cells in conditions inducing either IL-17A or F. Model analyses led to the identification of the transcription factors NFAT2A, STAT5A and Smad2 as key components explaining the differential expression of IL-17A and IL-17F, with STAT5A controlling IL-17F expression, and an interplay of NFAT2A, STAT5A and Smad2 controlling IL-17A expression.

OTHER RELATED OMICS DATASETS IN: PRJNA146093 PRJNA110559 PRJNA142285 PRJNA136635 PRJNA142287 PRJNA188245 PRJNA188248 PRJNA188243 PRJNA188244 PRJNA188241 PRJNA246420 PRJNA305162 PRJNA117127 GSE26553

SUBMITTER: Denis Thieffry  

PROVIDER: MODEL2101150001 | BioModels | 2021-04-06

REPOSITORIES: BioModels