Konstantinidis2021 - Persistence of mutants in a mutualistic microbial co-culture
Ontology highlight
ABSTRACT:
SUBMITTER: 
Eva Geissen
PROVIDER: MODEL2106100001 | BioModels | 2022-08-01
REPOSITORIES: BioModels
Publications
Adaptive laboratory evolution of microbial co-cultures for improved metabolite secretion.
Konstantinidis Dimitrios D Pereira Filipa F Geissen Eva-Maria EM Grkovska Kristina K Kafkia Eleni E Jouhten Paula P Kim Yongkyu Y Devendran Saravanan S Zimmermann Michael M Patil Kiran Raosaheb KR
Molecular systems biology 20210801 8
Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization. Here, we introduce coevolution of obligatory mutualistic communities for improving secretion of fitness-costly metabolites through natural selection. In this strategy, metabolic cross-feeding connects secretion of the target metabolite, despite its cost t ...[more]
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