Greene2025 - Hypoxia- and biomechanically driven EMT model

ABSTRACT: This model expands our "Regan2022 - Mechanosensitive EMT model with autocrine TGFbeta signaling" model (MODEL2208050002) with hypoxic signaling. It reproduces hypoxia-driven cell cycle arrest, the need for moderate Hif1-alpha activity for cell cycle progression, the mechanosensitive (density-dependent) nature of hypoxia-driven EMT. The model explores the succession of microenvironments and phenotype changes a metastatic cancer cell encounters from a primary tumor to a secondary site.

SUBMITTER: Erzsébet Ravasz Regan  

PROVIDER: MODEL2506050001 | BioModels | 2026-05-12

REPOSITORIES: BioModels