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Comparative genomic hybridization of seven strains of Clostridium difficile to investigate genome variability

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-38

INSTRUMENT(S): GeneQuant

ORGANISM(S): Clostridium difficile

SUBMITTER:

PROVIDER: E-BUGS-38 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.

Sebaihia Mohammed M Wren Brendan W BW Mullany Peter P Fairweather Neil F NF Minton Nigel N Stabler Richard R Thomson Nicholas R NR Roberts Adam P AP Cerdeño-Tárraga Ana M AM Wang Hongmei H Holden Matthew T G MT Wright Anne A Churcher Carol C Quail Michael A MA Baker Stephen S Bason Nathalie N Brooks Karen K Chillingworth Tracey T Cronin Ann A Davis Paul P Dowd Linda L Fraser Audrey A Feltwell Theresa T Hance Zahra Z Holroyd Simon S Jagels Kay K Moule Sharon S Mungall Karen K Price Claire C Rabbinowitsch Ester E Sharp Sarah S Simmonds Mark M Stevens Kim K Unwin Louise L Whithead Sally S Dupuy Bruno B Dougan Gordon G Barrell Bart B Parkhill Julian J

Nature genetics 20060625 7

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons. These mobile elements are putatively responsible for the acquisition by C. difficile of an extensive array of genes involved in antimicrobial resistance, virulence, host interaction and the production of surface structures. Th ...[more]

PMID: 16804543

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