Transcription profiling of human Wilms tumor samples to predicting relapse in favorable histology cases

ABSTRACT: The gene expression patterns of favorable histology Wilms tumors (FHWT) that relapsed were compared with those that did not relapse using oligonucleotide arrays; Description: 250 FHWT of all stages enriched for relapses treated on National Wilms Tumor Study 5 passed quality parameters and were suitable for analysis using oligonucleotide arrays. Relapse risk stratification utilized Support Vector Machine; two and ten fold cross-validation was applied. The number of genes associated with relapse was less than that predicted by chance alone for 106 patients (32 relapses) with stages I and II FHWT and no further analyses were performed. This number was greater than expected by chance for 76 local stage III patients. Cross validation including an additional 68 local stage III patients (total

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Perlman 

PROVIDER: E-GEOD-10320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress