Transcription profiling of human immortalized sebocytes (SEB-1) treated with 13-cis retinoic acid to gain insights into its sebocyte-specific mechanism of action

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE10432: 13-cis retinoic acid treatment of human sebocytes (SEB-1); GSE10433: Human Skin: Before and 1 week after Isotretinoin Treatment; The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Surprisingly, its mechanism of action in acne is still unknown. Gene expression profiling of cultured human immortalized sebocytes (SEB-1) treated with 13-cis RA was performed to gain insights into its sebocyte-specific mechanism of action. SEB-1 sebocytes were cultured with 0.1 uM 13-cis RA for 7

ORGANISM(S): Homo sapiens

SUBMITTER: Diane Thiboutot 

PROVIDER: E-GEOD-10434 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress