Transcription profiling of human chondrogenic progenitor cells in P1 of 3 male and 3 female patients with late-stage osteoarthritis in comparison to healthy chondrocytes in P1

ABSTRACT: The regeneration of diseased hyaline cartilage remains a great challenge, mainly because degeneration activities after major injury or due to age-related processes overwhelm the self-renewal capacity of the tissue. We show that repair tissue from human articular cartilage of late stages of osteoarthritis harbor a unique progenitor cell population, termed chondrogenic progenitor cells exhibiting stem cell characteristics, such as multipotency, lack of immune system activation and, in particular, migratory activity. The isolated CPC exhibit a high chondrogenic potential and were able to populate diseased tissue in vivo. Moreover, down-regulation of the osteogenic transcription factor runx-2 enhanced the expression of the chondrogenic transcription factor sox-9 and consequently the matrix syn

ORGANISM(S): Homo sapiens

SUBMITTER: Nicolai Miosge 

PROVIDER: E-GEOD-10575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress