Sm29 is a protective surface protein from the tegument of lung-stage Schistosoma mansoni

ABSTRACT: Schistosomiasis continues to be a significant public health problem1. Although vaccine development against this disease has experienced more failures than successes, encouraging results have recently been obtained using membrane-spanning protein antigens from the tegument of S. mansoni. Our group recently identified Sm29, an antigen that is predominantly recognized by IgG1 and IgG3 antibodies of resistant patients2. In the present study, we show that Sm29 is located on the surface of adult worms and lung-stage schistosomula. Immunization of mice with recombinant (r) Sm29 engendered 51% reduction in adult worm burdens, 60% reduction in intestinal eggs and 55% reduction in liver granulomas. Protective immunity in mice was associated with high titers of specific IgG1 and IgG2a and elevated p

ORGANISM(S): Schistosoma mansoni

SUBMITTER: Sergio Oliveira 

PROVIDER: E-GEOD-10777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress