Interference of hemozoin formation in Schistosoma mansoni by quinine reduces experimental schistosomiasis

ABSTRACT: Background: The parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel is still the only drug used for schistosomiasis treatment and reduction in drug efficiency has prompting the search for new therapeutic compounds against this disease. Our group has demonstrated that heme crystallization into hemozoin (Hz) within S. mansoni gut is a major heme detoxification route involving lipid droplets in this process and acting as a potential chemotherapeutical target. In the present work, we investigated the effects of the antimalarial quinine (QN) in a murine schistosomiasis model by using a combination of biochemical, cell biology and molecular biology approaches. Methodology/Principal Find

ORGANISM(S): Schistosoma mansoni

SUBMITTER: Marcus Oliveira 

PROVIDER: E-GEOD-14751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress