A Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle

ABSTRACT: Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication between insulin target tissues and beta-cells may initiate this compensatory response. Correlated changes in gene expression between tissues can provide evidence for such intercellular communication. We profiled gene expression in six tissues of mice from an obesity-induced diabetes-resistant and a diabetes-susceptible strain before and after the onset of diabetes. We studied the correlation structure of mRNA abundance and identified 105 co-expression gene modules. We provide an interactive gene netw

ORGANISM(S): Mus musculus

SUBMITTER: Eric Schadt 

PROVIDER: E-GEOD-10785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress